AG 556 is a selective inhibitor of EGFR with IC50 value of 1.1 μM. The epidermal growth factor receptor (EGFR) is the cell-surface receptor for epidermal growth factor and plays an important role in tumor invasion and cancer cell proliferation. AG 556 is a selective EGFR inhibitor. In HEK 293 cells expressing KIR2.3 or Kir2.1, AG556 (10 μM) reversibly reduced KIR2.3 or Kir2.1 currents. Also, AG556 inhibited tyrosine phosphorylation of KIR2.3 or Kir2.1 channels. EGF (100 ng/ml) increased KIR2.3 current, while this effect was inhibited by AG556 . AG556 arrested cells at G1/S phase by 85% and inhibited the activation of Cdk2 by phosphorylating tyrosine 15 on Cdk2 . In a canine model infected with Escherichia coli 0111: B4, AG 556 increased survival times. AG 556 increased mean arterial pressure, oxygen delivery, cardiac output, alveolar-arterial oxygen gradient and left ventricular ejection fraction, which suggested that AG 556 increased survival. Also, AG 556 significantly reduced the levels of serum TNF, which suggested that AG 556 inhibited cell-signaling pathways and cytokine-induced multiorgan failure .

Product information

CAS Number: 133550-41-1

Molecular Weight: 336.38

Formula: C20H20N2O3

Chemical Name: (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide

Smiles: N#C/C(=C\C1=CC(O)=C(O)C=C1)/C(=O)NCCCCC1C=CC=CC=1

InChiKey: GWCNJMUSWLTSCW-SFQUDFHCSA-N

InChi: InChI=1S/C20H20N2O3/c21-14-17(12-16-9-10-18(23)19(24)13-16)20(25)22-11-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-10,12-13,23-24H,4-5,8,11H2,(H,22,25)/b17-12+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.